Gautier S, Arpagaus C, Schafroth N, Meuri M, Deschamps A, Maquet V. Very fine chitosan microparticles with narrow & controlled size distribution using spray-drying technologies. Drug Deliv Technol. 2010;10:30-37.
This study explores the use of high-tech spray-drying methods to produce chitosan microparticles with precise size control. By employing a nano spray dryer, researchers successfully generated particles ranging from submicron to a few micrometers in diameter, achieving a narrow size distribution. The process parameters, including feed concentration, inlet temperature, and spray rate, were meticulously optimized to ensure consistency and reproducibility. These uniformly sized chitosan microparticles hold significant potential for pharmaceutical applications, particularly in drug delivery systems where particle size plays a crucial role in bioavailability and therapeutic efficacy.
Keywords: Chitosan microparticles, spray-drying technology, nano spray dryer, particle size control, drug delivery systems