Ferreres G, Ivanova K, Torrent-Burgués J, Tzanov T. Multimodal silver-chitosan-acylase nanoparticles inhibit bacterial growth and biofilm formation by Gram-negative Pseudomonas aeruginosa bacterium. J Colloid Interface Sci. 2023;646:576-586. doi: 10.1016/j.jcis.2023.04.184.
This study developed and evaluated multimodal nanoparticles composed of silver, chitosan, and acylase to combat Pseudomonas aeruginosa, a Gram-negative bacterium known for its resistance and biofilm-forming capabilities. The synthesized nanoparticles exhibited potent antibacterial activity, effectively inhibiting bacterial growth and disrupting biofilm formation. The combination of silver’s antimicrobial properties, chitosan’s biocompatibility, and acylase’s enzymatic activity contributed to a synergistic effect, enhancing the overall efficacy against P. aeruginosa. These findings suggest that silver-chitosan-acylase nanoparticles hold promise as a therapeutic strategy to address infections caused by biofilm-forming bacteria.
Keywords: Silver nanoparticles, chitosan, acylase, Pseudomonas aeruginosa, antibacterial, biofilm inhibition