Nascimento AV, Singh A, Bousbaa H, Ferreira D, Sarmento B, Amiji MM. Mad2 checkpoint gene silencing using epidermal growth factor receptor-targeted chitosan nanoparticles in non-small cell lung cancer model. Mol Pharm. 2014;11(10):3515-3527. doi: 10.1021/mp5002894.
This study developed epidermal growth factor receptor (EGFR)-targeted chitosan nanoparticles to deliver small interfering RNA (siRNA) against the Mad2 gene in non-small cell lung cancer (NSCLC) cells. The targeted nanoparticles demonstrated enhanced uptake in EGFR-overexpressing A549 cells, leading to significant Mad2 gene silencing and increased apoptotic cell death. These findings suggest that EGFR-targeted chitosan nanoparticles are a promising strategy for gene therapy in NSCLC.
Keywords: EGFR-targeted nanoparticles, chitosan, Mad2 gene silencing, siRNA delivery, non-small cell lung cancer